The latest research about Diabetes describes how in mice during the initial stages of type 2 diabetes, immune cells Which is known as macrophages plunder pancreatic tissue, secreting in a big amount of cytokines proinflammatory proteins that destroys the beta cells Which producing an insulin.
More than 3600 Lakhs people around the world are phasing type 2 diabetes including around 8% of Americans and 9% of Indians. The disease can cause of more dangerous conditions like blindness, loss of limbs, kidney failure and cardiovascular disease.
In healthy people without diabetes pancreas’s beta cells release insulin into the bloodstream that helps to maintain the level of blood sugar which goes high after eating.
According to Diabetes Researchers :
“The study provides new detailed information allowing development of ready-made anti-inflammatory based treatments reducing the Pain of type 2 Diabetics.”
The new treatments could be used where existing therapies are used currently, for example those that use insulin injections.
From their study, the researchers compared over weighty mice that Randomly developed diabetes to normal healthy mice.
They observed the mice from a young age, when the mice comes in adulthood so many of their organs are affected.
They supervised presence of macrophages around the insulin which is producing by beta cells of the pancreas, and also in the spleen. They used the advanced cytometric technology which allows them to take detailed reports even of single cells.
Pro-inflammatory macrophages ‘invade diabetic islets’
The result of an observations shows some differences which happened in the islets of the pancreas and the spleen between the diabetic mice and the healthy mice – both in the initial stages when they all were young and in the last stages when they all were become older.
Islets- the group of beta cells those are responsible for create and release insulin
Only 2 were observed as the nondiabetic littermates, whereas12 macrophages were observed in the diabetic islets.
They note how in the older diabetic mice the changes in the pancreas and spleen moved more toward a pro- inflammatory pattern:
In older stage of diabetes the cytokine signature changed toward a TGF-β-dominated profile, coinciding with a significant increase of galectin-3-positive macrophages in the spleen.
And this research proves that the Diabetes is the inflammatory disease.
Shiv Dixit is a keen follower of trends of Herbs for Diabetes in Ayurveda. He also has professional interests in the field and manages health related websites and blogs.